基本氧化在基本高血压中的合成
Lancet (London, England)
|March 22, 1997
概括
在患有基本高血压的患者中,氧化 (NO) 的产生较低. 这项研究测量了酸盐,NO的最终产物,以评估高血压患者的NO合成.
科学领域:
- 心血管研究研究心血管研究
- 内分泌学 在内分泌学.
- 代谢研究 代谢研究
背景情况:
- 基本高血压与血管内皮中氧化物 (NO) 合成的改变有关.
- 直接测量高血压中NO的产生是具有挑战性的.
- 酸盐是NO氧化过程的最终产物,是NO合成的生物标志物.
研究的目的:
- 直接估计未经治疗的基本高血压患者的氧化 (NO) 产量.
- 测量无机酸盐合成作为NO生产的指标.
- 为了研究血压与NO合成之间的关系.
主要方法:
- 进行了两项涉及高血压患者和健康对照者的研究.
- 研究1:饮食中酸盐摄入量,尿液/血中酸盐测量和24小时的门诊血压监测.
- 研究2:静脉注射L[15N]2氨酸,24小时的门诊血压监测和36小时的尿液收集以测量15N-酸盐.
主要成果:
- 高血压患者的24小时尿中酸盐分泌量与研究1中的对照人群相比显著降低 (p < 0.001).
- 在白天血压和酸盐分泌之间观察到显著的反相关性 (p = 0.007).
- 在研究2中,高血压患者表现出较低的36小时尿15N-酸盐分泌量 (p < 0.001) 和与血压的反相关性 (p = 0.002).
结论:
- 在基本条件下,全身氧化 (NO) 生产在患有基本高血压的患者中似乎减少.
- 测量的NO的确切来源尚未确定.
- 目前尚不清楚受损的NO合成是血压升高的主要原因还是后果.
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