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在狗冠状动脉绑定之前和之后,用propranolol减少心脏病发作的大小
Circulation
|November 1, 1977
概括
醇治疗通过防止中度缺血性心脏组织的细胞死亡,显著减少心肌梗塞的大小. 早期使用普拉诺洛尔 (在冠状动脉封闭之前) 比延迟治疗更有效.
科学领域:
- 心血管科学 心血管科学
- 药理学 药理学是指药理学的学科.
- 心肌缺血的研究研究心肌缺血.
背景情况:
- 冠状动脉封闭导致不可逆转的心肌细胞损伤,最初在心下内脏区域,并向外扩散.
- 了解缺血损伤的进展对于开发有效的治疗策略至关重要.
研究的目的:
- 评估罗对狗冠状动脉封闭后心肌缺血性损伤的进展的影响.
- 为了比较治疗前的疗效与延迟的普拉诺洛尔的使用.
主要方法:
- 研究了三组狗:未经治疗的,先前接受了普罗兰诺洛尔的治疗,并在绑定后三小时接受了普罗兰诺洛尔的治疗.
- 心肌亡的量化是在冠状动脉结合后24小时使用组织学分析.
- 微血管损伤和 perfusion 缺陷使用 thioflavin S. 染料进行了评估.
主要成果:
- 普罗兰醇显著降低了心脏病发作的大小,主要是通过防止外围,中度缺血区域的亡.
- 使用普拉诺洛尔的预治疗可以将缩症从85%降低到52% (P <0.05).
- 延迟的普拉诺洛尔治疗减少了缩至71% (P <0.05) 并不如治疗前有效. 普罗巴诺洛还限制了微血管损伤.
结论:
- 甲醇有效地限制了心脏病发作的大小,通过保护中度缺血性心肌从死中.
- 在冠状动脉封闭后的延迟治疗相比,早期使用普拉诺洛尔可以提供更大的心脏保护.
- 普罗兰醇可以减轻与心肌缺血相关的微血管损伤.
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