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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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前进的遗传方法取得了成功:克隆哺乳动物时钟基因

S M Reppert1, D R Weaver

  • 1Laboratory of Developmental Chronobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

Cell
|May 16, 1997
PubMed
概括

No abstract available in PubMed .

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Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...