移植前自然死亡和干细胞移植后的移植与宿主疾病之间的关联
Lancet (London, England)
|November 24, 1979
概括
在干细胞移植患者中评估了天然杀手 (NK) 细胞对简单疹病毒1型 (HSV-1) 感染细胞的活性. 正常的NK(HSV-1) 活动与移植与宿主疾病 (GvHD) 的发展相关,这表明NK细胞功能预测了GvHD.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 血液学 血液学 血液学
背景情况:
- 异构干细胞移植是一种复杂的程序,具有潜在的并发症,如移植与宿主疾病 (GvHD).
- 自然杀手 (NK) 细胞活动在免疫监测和对病毒感染的反应中发挥作用,包括单纯疹病毒1型 (HSV-1).
研究的目的:
- 研究移植前对感染HSV-1纤维细胞 (NK(HSV-1)) 的自然杀手细胞活性与在接受全源干细胞移植的患者中发展GvHD之间的关系.
- 要确定NK(HSV-1) 活动是否是一个宿主决定的函数,可以预测GvHD.
主要方法:
- 对接受异性骨髓或胎儿组织干细胞移植的患者进行前性研究.
- 在移植前测量NK ((HSV-1) 活性.
- 监测GvHD移植,生存和发展的证据.
主要成果:
- 13名患者存活了足够长的时间来发展GvHD.
- 七名移植前NK(HSV-1) 活性正常的患者都获得了GvHD.
- 六名移植前NK ((HSV-1) 活性较低的患者没有显示GvHD的证据.
- 这些发现独立于患者的准备,干细胞来源或细胞巨乳病毒感染.
结论:
- 移植前NK ((HSV-1) 活性似乎是GvHD发展的重要预测因素.
- NK(HSV-1) 试验可能反映了一个宿主决定的免疫功能,能够刺激GvHD.
- 这种测试可能有助于在干细胞移植接受者中对GvHD的风险分层.
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