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Updated: Aug 19, 2026

High-throughput Crystallization of Membrane Proteins Using the Lipidic Bicelle Method
07:26

High-throughput Crystallization of Membrane Proteins Using the Lipidic Bicelle Method

Published on: January 9, 2012

人类BPI的晶体结构和两个结合的脂在2.4安格斯特罗姆分辨率

L J Beamer1, S F Carroll, D Eisenberg

  • 1UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.

Science (New York, N.Y.)
|June 20, 1997
PubMed
概括

杀菌/增加透性的蛋白质 (BPI) 通过结合脂多糖化合物来中和阴性细菌. 它的晶体结构揭示了脂质结合口袋,为BPI提供了洞察力.

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Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...