bensodiazepine的使用和老年人机动车事故的风险
B Hemmelgarn1, S Suissa, A Huang
1Department of Epidemiology and Biostatistics, McGill University and Royal Victoria Hospital, Montreal, Québec, Canada.
JAMA
|July 2, 1997
概括
长半衰期的二增大老年司机的撞车风险,而短半衰期的二则没有. 这项研究强调了药物类型对老年人驾驶安全的重要性.
科学领域:
- 老年人药理学老年人药理学
- 交通安全研究 交通安全研究
- 流行病学 流行病学
背景情况:
- bensodiazepine 使用在老年人中很常见,可能会损害驾驶能力并增加机动车辆撞车 (MVC) 风险.
- 之前对二类药物和驾驶风险的研究已经产生了不一致的结果,可能是由于药物半衰期和使用持续时间的不同.
研究的目的:
- 调查使用二胺 (通过消除半衰期进行区分) 与老年司机受伤机动车事故的风险之间的关联.
主要方法:
- 采用了一个嵌套的病例控制研究设计,分析了加拿大北克州224734名年龄在67-84岁的司机 (1990-1993年) 的队列.
- 数据来源包括驾驶执照文件,警方关于伤害事故的报告和医疗保险记录.
- 病例是涉及伤害事故的司机 (n=5579),每例从一个子队列 (n=13,256) 随机抽取10个对照.
主要成果:
- 短期使用长半衰期二类药物与45%的车祸率比率增加有关 (RR,1.45;95% CI,1.04-2.03).
- 长期使用 (长达1年) 长半衰期的二氨酸显示显著但略低的风险增加 (RR,1.26;95% CI,1.09-1.45).
- 没有观察到在开始或继续使用短半衰期二胺类药物时发生车祸的风险增加.
结论:
- 暴露于长半衰期的二类药物,无论是短暂的还是延长的,都与老年司机发生机动车事故的风险更高有关.
- 短半衰期的二西平在这个老年人群中没有显示出高危的车祸风险.
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