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Bcl-2可以在缺少互白素-7受体的小鼠中拯救T淋巴细胞的发展,但不能在突变的拉格-1-/-小鼠中

E Maraskovsky1, L A O'Reilly, M Teepe

  • 1Department of Cellular Immunology, Immunex Research and Development Corporation, Seattle, Washington 98101, USA.

Cell
|June 27, 1997
PubMed
概括

互白素-7受体 (IL-7R) 信号传递可以防止T细胞在发育过程中死亡. 过度表达Bcl-2可在IL-7R缺乏的小鼠中挽救缺陷,但不能在缺乏T细胞前受体的小鼠中挽救缺陷.

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