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Bcl-2 拯救了interleukin-7受体缺乏的小鼠中的T淋巴发育

K Akashi1, M Kondo, U von Freeden-Jeffry

  • 1Department of Pathology, Stanford University School of Medicine, California 94305, USA.

Cell
|June 27, 1997
PubMed
概括

介素-7受体α (IL-7Rα) 信号传递对于T和B细胞发育至关重要. 在IL-7Rα缺乏的小鼠中强迫Bcl-2表达挽救了T细胞的发育,这表明IL-7Rα主要促进细胞存活.

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...