通过C-来预防糖尿病大鼠的血管和神经功能障碍
1Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Science (New York, N.Y.)
|July 25, 1997
概括
胰岛素生产的副产品C-,令人惊的是,在糖尿病老鼠中预防了血管和神经功能障碍. 它的效果源于非极性氨基酸,相互作用的非立体.
科学领域:
- 生物化学 生物化学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- C-是胰岛素合成过程中亲胰岛素分裂的副产物.
- 其除了胰岛素合成之外的生物活性在很大程度上尚未被探索.
- 糖尿病并发症包括血管和神经功能障碍.
研究的目的:
- 为了研究C-的潜在生物活性.
- 确定C-对糖尿病并发症影响的潜在机制.
- 确定C-的生物作用的结构要求.
主要方法:
- 给糖尿病老鼠注射人类C.
- 评估血管和神经功能 (电生理学).
- 测量Na+和K+依赖的腺三酸盐活性.
- 测试合成逆和反C-类型.
主要成果:
- 在糖尿病大鼠中,注射C可以预防或减少血管和神经功能障碍.
- 减弱的C-减弱的Na+和K+依赖的腺三酸盐活性.
- 中部分的非极性氨基酸对这些效应至关重要.
- 复古和enantioC-显示出与原生C-具有相似的效力.
结论:
- 在胰岛素合成之外,C-具有显著的生物活性.
- C-可以改善糖尿病患者的血管和神经功能障碍.
- C-的治疗效果是由非性相互作用介导的,而不是立体特异性的结合.
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