葡萄糖皮质体受体调节人类中性粒细胞上L-选择素和CD11/CD18的表达
J G Filep1, A Delalandre, Y Payette
1Maisonneuve-Rosemont Hospital, Department of Medicine, University of Montréal, Québec, Canada.
Circulation
|July 1, 1997
概括
葡萄糖皮质类药物特别影响激活的中性粒细胞粘附分子,减少白细胞积累. 这种抗炎作用涉及葡萄糖皮质体受体和蛋白质合成,为皮质类固醇作用提供了一个新的机制.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 葡萄糖皮质类药物可以通过降低内皮质粘附分子的调节来抑制白细胞向炎症组织的流通.
- 这项研究调查了葡萄糖皮质体对人类中性粒细胞L-选择素和CD11/CD18整体蛋白表达的影响.
研究的目的:
- 为了确定糖皮质类药物是否调节人类中性粒细胞上的L-选择素和CD11/CD18整体蛋白表达.
- 阐明葡萄糖皮质体对中性粒细胞粘附分子的作用机制.
主要方法:
- 人的全血被刺激了血小板激活因子 (PAF).
- 中性粒细胞表达L-选择素和CD11/CD18通过流细胞计测量.
- 在RU-486和循环赫西米德的存在下评估了甲的作用.
主要成果:
- 在中性粒细胞中,PAF诱导了L-选择素的降调和CD11/CD18的上调.
- 德克萨米他减弱了PAF诱导的L-选择素和CD18的变化,这种变化取决于时间和度.
- 德克萨米他的作用被RU-486和循环赫西米德阻断,这表明受体介导和蛋白质合成依赖的机制.
结论:
- 葡萄糖皮质类药物在临床相关度下调节活性中性粒细胞上的粘附分子表达.
- 这些效应通过葡萄糖皮质体受体结合和蛋白质合成诱导进行介导.
- 这表明抗炎性皮质类固醇抑制白细胞积累的新机制.
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