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与年龄相关的血压变化的血液动力学模式. 弗雷明汉心脏研究
S S Franklin1, W Gustin, N D Wong
1Heart Disease Prevention Program, University of California, Irvine 92697, USA.
Circulation
|July 1, 1997
概括
随着年龄的增长,血压发生变化,表现为静脉压升高和静脉压晚期下降. 这种模式,特别是在未经治疗的高血压中,表明动脉硬度增加.
科学领域:
- 心血管研究的心血管研究.
- 老龄化和生理学
- 高血压机制 高血压机制
背景情况:
- 在正常血压和未经治疗的高血压个体中调查与年龄相关的血压 (BP) 变化.
- 利用来自弗雷明汉心脏研究的基于人口的队列.
- 推断血压变化的潜在血液动力学机制.
研究的目的:
- 描述系统血压 (SBP) 和透气血压 (DBP) 中与年龄相关的变化.
- 探索血液动力学机制,包括平均动脉压 (MAP) 和脉冲压 (PP).
- 检查与基线SBP相关的BP跟踪模式.
主要方法:
- 对2036名参与者的长达30年的两年一次的BP数据进行分析 (检查2-16).
- 排除接受抗高血压药物治疗的受试者.
- 血压与年龄的回归分析,比较SBP组的斜率和曲率估计,使用ANOVA.
主要成果:
- SBP (30-84岁) 的线性增加和DBP和MAP的同时增加.
- 在50-60岁后:DBP下降,PP急剧上升,MAP平稳.
- 与年龄相关的BP变化,特别是分歧跟踪,在基线SBP较高的个体中更为明显.
结论:
- 60岁后的晚期DBP下降,随着SBP的上升,表明大动脉硬度增加.
- 这种现象并不能用"燃烧"高血压或"选择性生存"来解释.
- 未经治疗的较高SBP可能会加速动脉硬,从而产生有害的循环.
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