慢性心力衰竭中的荷尔蒙变化和代谢/代谢不平衡及其对心脏缓解症的重要性
S D Anker1, T P Chua, P Ponikowski
1Cardiac Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK. s.anker@ic.ac.uk
Circulation
|July 15, 1997
概括
心力衰竭中的心脏缓解症与荷尔蒙失衡有关,而不仅仅是疾病的严重程度. 改变的新陈代谢和荷尔蒙变化导致这种消耗综合征,严重影响患者的健康.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢研究研究 代谢研究
背景情况:
- 心脏失败中体重减轻的复杂综合征心脏失败的复杂综合征心脏卡赫西亚有不清楚的潜在机制.
- 荷尔蒙和细胞因子失调被怀疑是导致心脏缓冲症发展的因素.
研究的目的:
- 调查激素和细胞因子概况与慢性心力衰竭 (CHF) 患者心脏卡赫西亚的存在之间的关系.
- 为了比较神经激素激活和化/催化平衡在卡切克性与非卡切克性CHF患者和健康对照中.
主要方法:
- 评估疾病严重程度的标志物 (例如,最大氧气消耗,射出分数) 和健康对照组,非卡切克性心血管疾病患者和卡切克性心血管疾病患者的合成/代谢因子的血度.
- 利用多重回归分析来识别与浪费相关的独立因素.
主要成果:
- 与对照和非卡赫西克患者相比,卡赫西克性CHF患者的血含量降低,上腺素,上腺素,皮质醇,瘤缩因子-α (TNF-α) 和人体生长激素增加.
- 胰岛素,皮质醇,TNF-alpha和上腺素独立地与CHF患者的衰竭相关.
- 像胰岛素样生长因子-1,和雌激素这样的合成代谢因子在各组中都相似,而脱水氨在卡切克患者中减少.
结论:
- 荷尔蒙变化与心脏卡赫克西亚的关联比传统的衡量心脏衰竭严重程度更强.
- 在CHF中,心脏卡赫西亚的进展可能是由代谢和合成代谢之间的代谢平衡中断所驱动的.
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