在年轻人中产生上腺素的异常释放,具有较高的个人和父母高血压
S B Harrap1, R Fraser, G C Inglis
1Medical Research Council Blood Pressure Unit, Western Infirmary, Glasgow, UK. s.harrap@physiology.unimelb.edu.au
Circulation
|July 15, 1997
概括
年轻人的高血压与增加的体重和胰岛素水平有关,反映了生活方式因素. 独特的上腺素反应表明,高血压患者和家族病史中遗传和环境影响的结合.
科学领域:
- 心血管生理学心血管生理学
- 代谢综合征是代谢综合征的一种.
- 高血压研究 高血压研究
背景情况:
- 交感神经系统活动与高血压有关.
- 饮食和体重是导致高血压 (BP) 的潜在因素.
- 这项研究调查了来自家庭具有确定的BP历史的年轻成年人BP倾向.
研究的目的:
- 确定饮食和体重对高血压倾向的作用.
- 检查同情神经系统活动和BP之间的关系.
- 研究影响高血压的遗传和环境因素.
主要方法:
- 研究了100名患有高血压或低血压的年轻人,以及已知的父母血压.
- 在口服前和口服后测量了血甲基胺,葡萄糖和胰岛素水平.
- 分析了生理标志物和血压之间的相关性,考虑到家族史.
主要成果:
- 禁食的血诺阿基尼林与平均动脉压有显著的相关性.
- 高血压的个体更重,更胖,并且在葡萄糖后显示出更大的胰岛素上升.
- 患有高血压和父母有高血压病史的后代在葡萄糖后表现出异常的上升上腺素.
结论:
- 高血压与体重增加和高胰岛素血症有关,反映了个人环境和行为.
- 高血压患者的异常上腺素释放与家族病史表明遗传,环境和行为因素的结合.
- 个人环境和行为显著影响高血压,独立于家族病史.
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