在非Q波冠状动脉综合征中对罗西胺素的随机试验:ROXIS试点研究. 罗克西斯研究小组的研究小组
E Gurfinkel1, G Bozovich, A Daroca
1Favalore Foundation, Buenos Aires, Argentina. gurfi001@ffinme.edu.ar
Lancet (London, England)
|August 9, 1997
概括
针对Chlamydia pneumoniae的抗生素罗西胺显著减少了患有不稳定性胸痛的患者的主要缺血事件. 这项试点研究表明,抗甲状腺素治疗可能有利于冠状动脉疾病患者.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 血清学证据将克拉米迪亚肺炎感染与冠心病 (CHD) 联系起来.
- 研究了宏类抗生素罗西思罗米的潜力,以预防不稳定性胸痛患者的复发性缺血事件.
研究的目的:
- 评估罗西胺在诊断为心痛不稳定或非Q波心肌梗塞的患者中减少主要缺血事件的疗效.
主要方法:
- 这是一项双盲,随机,安慰剂控制的试点研究,涉及202名患者.
- 患者在30天的时间内接受了罗西胺素 (150毫克每天两次) 或安慰剂.
- 随访时间为6个月,主要终点在第31天进行评估.
主要成果:
- 在罗西组 (p=0.032) 中观察到心脏缺血性死亡,心肌梗塞和重复性严重缺血的复合终点的统计学显著降低.
- 与安慰剂相比,罗西菌素组的这些事件发生率明显较低.
- 没有报告与罗西胺素相关的重大不良反应.
结论:
- 抗甲状腺菌抗生素,如罗西胺素显示希望作为冠状动脉疾病患者的辅助治疗.
- 需要进一步的大规模临床试验来验证这些初步发现.
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