血管激素转化酶基因I/D多态的关联与左心室质量的变化,以应对体育训练
H E Montgomery1, P Clarkson, C M Dollery
1The Hatter Institute for Cardiovascular Research University College, London Medical Schools, University College Hospital, UK.
Circulation
|August 5, 1997
概括
ACE I/D 多态性影响运动诱导的左心室 (LV) 增长. 与II基因型相比,具有DD基因型的个体表现出明显更大的LV质量增加和LV缩.
科学领域:
- 遗传学 是一个遗传学.
- 心血管生理学心血管生理学
- 运动科学 运动科学
背景情况:
- 血管激素转化酶 (ACE) 基因I/D多态性影响ACE水平.
- 删除等位基因 (D) 与更高的ACE水平有关,而不是插入等位基因 (I).
- 氨酸- ангиотензин系统在左心室 (LV) 的生长中起作用.
研究的目的:
- 为了研究ACE I/D多态和运动诱导的LV缩之间的关联.
- 为了确定ACE基因型是否会影响对体育训练的过度缩反应.
主要方法:
- 研究了140名男性高加索裔军人新兵,他们接受了为期10周的体育训练计划.
- 使用心声学和心电学评估 LV 尺寸,质量和 LV 缩.
- 测量了血大脑性尿素 (BNP) 水平.
主要成果:
- 训练增加了18%的LV质量 (P<.0001),具有显著的基因型依赖差异.
- 平均 LV 质量变化为 +2.0g (II), +38.5g (ID) 和 +42.3g (DD) (P<.0001).
- 只有在DD基因型组 (P<.01) 中,LV缩患病率显著增加 (P<.01).
- 在DD的血BNP水平比II基因型增加更多 (P<.001).
结论:
- 年轻男性的运动诱导的LV增长与ACE I/D多态性密切相关.
- DD基因型与对运动训练有更强的缩反应有关.
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