一个多基因家族,编码哺乳动物中各种各样的假定激素受体
1Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cell
|August 22, 1997
概括
哺乳动物在鼻器官中使用一种新型的费洛蒙受体家族 (VRs) 来检测特定的气味. 这些受体以分布式模式表达,这表明一个复杂的感官编码系统.
科学领域:
- 哺乳动物感官神经科学
- 嗅觉受体遗传学 嗅觉受体遗传学
背景情况:
- 吐口鼻子器官 (VNO) 对于检测哺乳动物中的费洛蒙至关重要.
- VNO感觉神经元表达出不同的G蛋白,Gααo和Gααi2).
研究的目的:
- 在VNO神经元的Gα{o}+子集中识别新型候选费洛蒙受体 (VRs).
- 研究这些VR的表达模式和进化关系.
主要方法:
- 单个神经元基因表达分析以识别VRs.
- 染色体映射以探索进化联系.
- 对VR mRNA形式的分析.
主要成果:
- 发现了一种新的多基因家族,在Gααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααoαααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααααα.
- VRs以不同的间隔神经元来表达,表明分布式感官编码.
- 建议VR基因与挥发性气味受体之间的进化联系,以及结构分歧.
结论:
- 一组多样化的VRs有助于哺乳动物的费洛蒙检测.
- VNO采用一种分布式编码策略来对嗅觉刺激进行编码.
- 进化已经形成了不同的分子机制来检测不同的感官线索.
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