经过塞特拉林治疗,经月经前失调障碍的症状改善. 一个随机对照试验.一个随机对照试验. 塞特拉林 premenstrual Dysphoric 合作研究小组
K A Yonkers1, U Halbreich, E Freeman
1Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 75235, USA.
JAMA
|November 5, 1997
概括
在患有月经前失调障碍 (PMDD) 的女性中,塞特拉林显著改善了症状和功能障碍. 这项研究表明,塞特拉林是一种有效的PMDD治疗选择,可以缓解情绪和身体症状.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 妇女健康 妇女健康
背景情况:
- 月经前失调障碍 (PMDD) 显著影响到经期妇女的生活.
- 对PMDD的有效治疗对于改善妇女福祉至关重要.
研究的目的:
- 评估塞特拉林化在治疗月经前失调症中的疗效.
- 测量PMDD患者症状严重程度和功能障碍的变化.
主要方法:
- 一项随机,双盲,安慰剂对照试验,涉及243名患有PMDD的女性.
- 灵活的每日剂量塞特拉林 (50-150毫克) 在三个周期内被使用.
- 症状严重程度和功能障碍使用经过验证的尺度来评估.
主要成果:
- 与安慰剂相比,塞特拉林治疗导致每日症状得分显著降低 (P<.001).
- 在抑郁症,身体和愤怒/易怒症状集群中观察到改善 (P<.05).
- 全球评级显示,在接受塞特拉林治疗的62%患者中,有很大或非常大的改善,而在安慰剂组中,这一比例为34% (P<.001).
结论:
- 塞特拉林在缓解PMDD症状和功能障碍方面显著优于安慰剂.
- 选择性血清素再吸收抑制剂 (SSRI) 如塞特拉林是管理PMDD的有价值的治疗选择.
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