在患有高危脂质特征的儿童中,被动吸烟和降低HDL胆固醇水平
E J Neufeld1, M Mietus-Snyder, A S Beiser
1Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, Mass 02115, USA. neufeld@a1.tch.harvard.edu
Circulation
|October 7, 1997
概括
暴露于二手烟的儿童的HDL胆固醇水平较低. 这种被动吸烟的暴露是患有脂质障碍的年轻人中HDL胆固醇降低的重要危险因素.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 环境健康 环境健康
- 脂质代谢 脂质代谢是什么
背景情况:
- 在活跃吸烟者中观察到降低高密度脂蛋白 (HDL) 胆固醇.
- 之前的研究表明,被动吸烟与儿童的低HDL之间存在联系,但缺乏对混因素的调整.
研究的目的:
- 调查被动吸烟与儿童和青少年患有脂质不良症的高密度胆固醇水平之间的关联.
- 评估被动吸烟是否是该人群中降低HDL胆固醇的独立风险因素.
主要方法:
- 在超脂血症诊所对103名儿童和青少年 (2-18岁) 进行了一项横截面试验.
- 收集的数据包括社会人口统计,饮食,病史和禁食脂质概况.
- 多变量回归分析根据体重指数,年龄,性别,运动和饮食脂肪摄入量进行调整.
主要成果:
- 暴露在被动烟雾中的儿童的高密度胆固醇水平 (38.7 mg/dL) 与未暴露的儿童相比 (43.6 mg/dL) 显著降低.
- 被动吸烟与其他脂质值没有显著的关联.
- 在调整了混因素后,被动吸烟仍然是降低HDL胆固醇的重要危险因素 (P=.012).
结论:
- 来自有吸烟者家庭的失脂症儿童的平均高脂胆固醇水平较低.
- 在高危的年轻人中,被动烟雾暴露可能会加剧未来动脉样硬化风险.
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