活性血清维生素D水平与冠状动脉化相反相关
K E Watson1, M L Abrolat, L L Malone
1Department of Medicine, University of California, Los Angeles School of Medicine, and Harbor-University of California, Los Angeles Medical Center, 90095, USA. kwatson@medicine.medsch.ucla.edu
Circulation
|October 10, 1997
概括
低维生素D水平与心脏病风险较高的人群的动脉化增加有关. 这表明维生素D可能在血管化和骨质疏松症与血管化相关性中发挥作用.
科学领域:
- 心血管研究研究心血管研究
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 动脉化在动脉样硬化中很普遍,在90%以上的重大病变中发现.
- 动脉样硬化化的发展与骨质生成有相似之处,促使对骨质调节因素的研究.
研究的目的:
- 研究骨质调节因子在动脉化中的潜在作用.
- 评估血管化与关键骨质调节分子的血清水平之间的关联.
主要方法:
- 研究了两个人群 (173名受试者) 具有冠心病的高风险和中等风险.
- 测量了骨素,副甲状腺激素和1alpha,25-dihydroxyvitamin D3 (1,25-维生素D) 的血清水平.
- 评估了血管化程度和血清分子水平之间的相关性.
主要成果:
- 在两组研究中,血清1,25-维生素D水平与血管化程度呈反相关性.
- 血管化和血清骨质卡尔辛或副甲状腺激素水平之间没有明显的相关性.
结论:
- 数据表明,维生素D在血管化的发展中可能发挥作用.
- 1,25-维生素D可能有助于骨质疏松症和血管化之间的确立联系,因为它在骨矿化中的作用.
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