在预条件后24小时延迟冠状动脉内皮细胞保护:自由基的作用
N Kaeffer1, V Richard, C Thuillez
1Department of Pharmacology, Vacomed, Rouen University School of Medicine and Rouen Hospital, France.
Circulation
|October 23, 1997
概括
前置条件 (PC) 提供了延迟保护,以防止冠状动脉内皮损伤后缺血/再输液 (I/R). 在PC过程中产生的反应性氧物种是冠状动脉内皮中这种晚期保护作用的关键触发因素.
科学领域:
- 心血管生物学 心血管生物学
- 内皮细胞功能 内皮细胞功能
- 缺血-再输液损伤 缺血-再输液损伤
背景情况:
- 已知预制 (PC) 诱导了对肌肉心缺血/反 (I/R) 损伤的延迟保护.
- 在冠状动脉内皮细胞中存在类似的晚期保护作用的存在仍未得到研究.
- 这项研究探讨了PC对内皮I/R损伤的晚期保护以及反应性氧物种 (ROS) 的作用.
研究的目的:
- 为了确定PC是否在I/R之后提供了对冠状动脉内皮损伤的晚期保护.
- 研究ROS作为冠状动脉内皮细胞中晚期PC触发者的作用.
主要方法:
- 老鼠接受了假手术或PC使用特定的I / R周期.
- 二十四小时后,老鼠接受了长时间的I / R,有或没有自由基清除剂N-2-mercaptopropionyl glycine (MPG).
- 冠状动脉细分被隔离并评估了依赖于内皮细胞的放松到乙胆的情况,使用线程肌图.
主要成果:
- I/R显著减少了冠状动脉段中乙胆诱导的放松.
- MPG 防止了 I/R 诱导的放松障碍.
- PC在I/R后改善了内皮功能,但MPG取消了这一好处,表明ROS参与.
结论:
- PC诱导了延迟的保护作用,防止再注射诱导的冠状动脉内皮损伤.
- 在PC过程中产生的ROS不仅作为损伤的调解剂,而且作为冠状动脉内皮对I/R的晚期保护的关键触发剂.
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