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Updated: Jun 9, 2026

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由于DNA损伤引起的p53酸化减轻了MDM2的抑制作用

S Y Shieh1, M Ikeda, Y Taya

  • 1Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Cell
|November 18, 1997
PubMed
概括

DNA 损伤会通过酶15的酸化触发p53的激活,从而减少它与MDM2.2的相互作用. 这种酸化,特别是由DNA依赖蛋白激酶 (DNA-PK) 进行的酸化,增强了p53的活性.

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