成年人先前感染水病史的可靠性
M R Wallace1, C J Chamberlin, L Zerboni
1Internal Medicine Department, Naval Medical Center, San Diego, Calif 92134-5000, USA. mwallace@snd10.med.navy.mil
JAMA
|November 18, 1997
概括
许多患有水的成年人声称先前感染过水,但实验室测试显示他们可能从未患过水 (水). 真正的第二次水发作在健康的成年人中很罕见,质疑历史可靠性.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 偶尔在免疫能力强的个体中报告了明显的第二次水发作 (水).
- 实验室确认先前的免疫力是具有挑战性的,这使得很难区分真正的再感染和初级病例.
研究的目的:
- 为了评估报告有水病史的水患者的成年患者.
- 为了确定这些是否代表了真正的第二次发作或具有不准确历史的初级感染.
主要方法:
- 在一项抗病毒试验中的成人水患者接受了关于先前水病史的采访.
- 在急性疾病发生之前采集的血清样本被测试出疹病毒 (VZV) 的IgG抗体,使用ELISA,乳聚合和西班牙血清测试.
- 临床过程被前性地记录.
主要成果:
- 在184名被证实患有水的成年人中,有20人 (10.8%) 报告了先前的病史.
- 这些受试者中的19人患病前血清样本缺乏VZV IgG抗体.
- 在那些有和没有报告过水病史的人群中,临床表现没有差异.
结论:
- 在目前患有水的成年人中,自我报告的先前水感染史可能不可靠.
- 真正的第二次水发作在免疫能力强的成年人中可能很少发生.
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