关于蛋白质家族的基因组视角
R L Tatusov1, E V Koonin, D J Lipman
1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
概括
研究人员通过对不同基因组中的蛋白质进行比较,将保存的基因分类为720个正统组集群 (COG). 这一框架有助于理解基因功能和进化关系,特别是对于表征不佳的基因组.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 进化生物学 进化生物学
背景情况:
- 基因组测序正在迅速发展,产生大量的数据.
- 基于同质性的保存基因的分类对于提取最大信息至关重要.
- 了解同源关系有助于功能和进化基因组分析.
研究的目的:
- 通过它们的同类关系来分类保存的基因.
- 建立功能性和进化基因组分析的框架.
- 为了使功能预测为不好地表征的基因组.
主要方法:
- 对七个完整基因组中编码的蛋白质的比较分析,来自五个主要的基因谱系.
- 阐明序列相似性的一致模式.
- 划定正统群组 (COG) 集群的界限.
主要成果:
- 确定了720个正统群组 (COG) 的集群.
- 每个COG包括来自至少三种谱系的正统蛋白质或对应蛋白.
- 发现正义学家通常具有相同的功能.
结论:
- COGs为功能和进化基因组分析提供了一个框架.
- 功能信息可以在COG中转移,有助于对非特征化的基因组进行预测.
- 这种分类系统提高了积累基因组序列数据的实用性.
相关概念视频
Gene Families
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Protein Families
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...
Conservation of Protein Domains Over Different Proteins
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Gene Families
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Protein Families
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...
Conservation of Protein Domains
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...


