将除模型应用于人类除数据:对于优化植入式除器容量能力的影响
C D Swerdlow1, J E Brewer, R M Kass
1Department of Medicine, Cedars-Sinai Medical Center, and University of California Los Angeles School of Medicine, 90048, USA. swerdlow@ucla.edu
Circulation
|December 31, 1997
概括
理论模型使用人类心肌时间参数准确预测可植入心脏转换器-除器 (ICD) 电容. 通过大约90微法拉德电容器,可以实现最佳的ICD功能和降低除门 (DFT).
科学领域:
- 生物医学工程 生物医学工程
- 心脏病学 心脏病学
- 医疗器械技术 医疗器械技术
背景情况:
- 理论模型表明,最佳的植入式心脏转换器-除器 (ICD) 电容与强度-持续时间关系参数相关.
- 过度模型将平均电流与chronaxie (t(c) 相关联,而指数模型将前沿电流与膜时间常数 (tau(m)) 相关联.
- 这项研究测试了这些模型是否使用人类时间常数预测临床ICD电容结果.
研究的目的:
- 为了评估理论模型的预测准确度,以获得最佳的ICD电容.
- 在预测除门 (DFT) 中比较平均电流和前沿电流模型.
- 为了确定模型预测和ICD电容性的临床研究之间的相关性.
主要方法:
- 研究了12名心上心脏病患者和15名静脉输入性心脏病患者,确定了各种脉冲宽度的DFT.
- 导出了一个新的指数平均电流模型,与现有模型进行比较.
- 计算了每个模型的个体患者时间参数,并根据临床数据验证了预测.
主要成果:
- 这三种模型都显示出与数据的良好匹配 (r2=0.880.97,P<.001).
- 透静脉通路的时间常数比表心通路的时间常数低 (P<.001).
- 模型预测与临床研究的相关性很好 (r2=0.750.84,P<.003),表明可以使用~90微法拉德电容器实现最佳电容.
结论:
- 使用测量的人类心肌时间参数的模型预测与临床ICD电容性研究相对应.
- 通过大约90微法拉德电容器,可以实现最佳的ICD性能和显著的DFT减少.
- 这些发现支持使用理论模型来优化ICD设备设计和编程.
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