运动诱导的ST段抑郁症的心率调整确定了从降低风险因素计划中受益的男性
P M Okin1, R J Prineas, G Grandits
1Department of Medicine, The New York Hospital-Cornell Medical Center, New York 10021, USA. pokin@mail.med.cornell.edu
Circulation
|December 31, 1997
概括
异常的ST/HR指数可以识别患冠心病 (CHD) 死亡的高风险男性. 在这些男性中,降低风险的疗法显著降低了61%的心脏病死亡率.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 运动生理学 运动生理学
背景情况:
- 冠心病 (CHD) 风险分层对于预防策略至关重要.
- 对运动诱导的ST段抑郁症,调整为心率的个体,风险因素修改的好处仍然不清楚.
研究的目的:
- 调查使用心率调整后运动诱导的ST段抑郁症的男性是否有增加心脏病死亡风险,受益于降低风险因素的治疗.
主要方法:
- 分析了来自多重风险因素干预试验 (MRFIT) 的11880名男性的大队.
- 参与者被分为常规护理 (UC) 和特殊干预 (SI) 组.
- 通过ST段抑郁和ST段/心率 (ST/HR) 指数>1.60微伏/bpm定义了一个异常的ST段反应.
主要成果:
- 与UC男性相比,心脏病死亡率在异常ST/HR指数的SI男性中明显较低 (2.4%对5.3%,P=.005).
- 在SI和UC男性与正常ST/HR指数之间没有观察到心血管疾病死亡率的显著差异.
- 具有异常ST/HR指数的SI组的风险降低独立于其他心脏风险因素.
结论:
- 异常的ST/HR指数有效地识别了无症状的男性,他们从降低风险因素的治疗中获得了显著的好处.
- 这种方法在经过风险因素修改的男性中发现,心血管疾病死亡风险降低了61%.
- 心率调整ST抑郁症是一种有价值的查工具,用于识别从心脏病预防计划中获益最多的个人.
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