血清粉样蛋白A蛋白与冠状动脉疾病之间的关联:来自两个不同的动脉硬化过程的证据
A I Fyfe1, L S Rothenberg, F C DeBeer
1Department of Medicine, Molecular Biology Institute, UCLA, Los Angeles, Calif 90095-1679, USA. afyfe@medicine.medsch.ucla.edu
Circulation
|December 31, 1997
概括
血清粉样蛋白A (SAA) 蛋白水平在患有冠状动脉疾病的患者中升高,无论是自发的还是与移植相关的. 这些较高的SAA水平与移植后的死亡率增加相关,并表明炎症和动脉样硬化之间存在联系.
科学领域:
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
- 脂质代谢 脂质代谢是什么
背景情况:
- 血清粉样蛋白A (SAA) 蛋白质是炎症性无脂蛋白,影响高密度脂蛋白 (HDL) 功能.
- 升高的SAA水平与不稳定的冠状动脉综合征有关.
- 自发性或移植性冠状动脉疾病 (CAD) 的SAA水平和类型以前是未知的.
研究的目的:
- 确定自发性和移植相关冠状动脉疾病患者的SAA蛋白水平和类型.
- 调查SAA水平与心血管疾病之间的关联.
- 探索SAA,炎症和动脉样硬化之间的关系.
主要方法:
- 与酶相关的免疫吸收试验 (ELISA) 用于量化患者血清中的SAA水平.
- 来自心脏移植患者和动脉样硬化CAD患者血清的分析.
- 免疫注射用于识别SAA蛋白类型.
主要成果:
- 与正常人相比,移植患者的平均SAA水平明显高 (5倍).
- 移植CAD患者的SAA水平较没有移植CAD患者的SAA水平高.
- 增加的SAA水平与移植后死亡率的增加有关.
- 与未受影响的亲属相比,自发动脉硬化CAD患者的SAA水平也升高.
- 皮质类固醇剂量,移植前CAD和移植CAD预测了SAA水平.
结论:
- 环境决定的SAA水平的升高存在于自发性和移植性CAD中.
- 这些发现支持了炎症,脂蛋白代谢和动脉样硬化发展之间的病理生理联系.
- SAA可能在冠状动脉疾病的进展中发挥作用.
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