关于旅行者预防疟疾的最新情况
1Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. hol1@cdc.gov
JAMA
|December 5, 1997
概括
医疗保健提供者必须保持最新的疟疾预防,特别是对于旅行者. 建议服用梅花,但耐药性和副作用需要仔细考虑替代品和合理使用药物.
科学领域:
- 医学科学 医学科学 医学科学
- 热带医学 热带医学
- 药理学 药理学 是一个学科.
背景情况:
- 向疟疾流行地区的国际旅行需要为旅行者更新疟疾预防策略.
- 抗疟药物耐药性和耐受性特征的不断变化需要定期审查指南.
- 需要特别注意对抗抗克洛洛昆耐药的Plasmodium falciparum疟疾的预防.
研究的目的:
- 对旅行者进行疟疾预防 (化疗预防) 的当前建议进行审查.
- 讨论常用的抗疟疾药物的疗效,耐受性和限制.
- 突出合理使用毒品和未来药物开发的需要.
主要方法:
- 审查目前关于疟疾化学预防的指导方针和文献.
- 对Plasmodium falciparum的药物敏感性模式的分析.
- 对抗疟疾药物的不良影响概况和禁忌的评估.
主要成果:
- 梅花素是大多数旅行者的首选预防药物,尽管东南亚出现了耐药性和有关副作用的事担忧.
- 多西环素是一种替代药物,但需要每天服用,并且有禁忌.
- 氨酸仅在特定的地理区域 (中美洲,加勒比海,中东部分地区) 有效.
结论:
- 合理使用现有的抗疟疾药物对于延长其有效性至关重要,因为新药开发有限.
- 持续研究和开发新的抗疟疾药物对于未来的疟疾预防至关重要.
- 医疗保健提供者必须了解当前的疟疾预防指南,以确保旅客的安全.
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