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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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腺环酶激活剂Gsalpha 的晶体结构

R K Sunahara1, J J Tesmer, A G Gilman

  • 1Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9041, USA.

Science (New York, N.Y.)
|January 7, 1998
PubMed
概括

用GTPgammaS.揭示了关键信号蛋白质Gsalpha的晶体结构. 与Gialpha相比,其结构的差异解释了效应器的特异性和与信号调节器的相互作用.

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