氧化涂层除电极:减少冲击偏振和改善除功效
M J Niebauer1, B Wilkoff, Y Yamanouchi
1Department of Cardiology, The Cleveland Clinic Foundation, Ohio 44195, USA. niebaum@cesmtp.ccf.org
Circulation
|December 13, 1997
概括
植入式心脏转换器-除器 (ICD) 上的氧化 (IROX) 涂层导致猪除所需的能量显著减少. 这种IROX涂层还将阻抗上升降至最低,表明电极极化减少.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 材料科学 材料科学 材料科学
背景情况:
- 透静脉植入式心脏转换器-除器 (ICD) 导线对于通过电击终止心室节律失常至关重要.
- 不同的材料对除效率的影响仍未得到充分研究.
- 这项研究研究了用氧化 (IROX) 涂覆的ICD与未涂覆的进行对比,以评估材料的影响.
研究的目的:
- 为了比较一种有氧化 (IROX) 涂层的可植入心脏转换器-除器 (ICD) 与未涂层的的除功效.
- 为了评估 IROX 涂层对电极极化和除过程中阻抗的影响.
- 为了确定IROX涂层是否可以降低成功除所需的能量.
主要方法:
- 这项研究涉及13头猪,比较了IROX涂层和未涂层的ICD导线.
- 使用两种类型与未涂层的电极配对来确定除门 (DFT).
- 通过使用特罩来交换,以确保一致的心内定位.
主要成果:
- 与未涂层的 (19.1+/-5.1 J;P<.006) 相比,IROX涂层的显示出明显较低的输送能量DFT (15.9+/-5.4 J).
- 在DFT.的IROX涂层和未涂层线之间,初始阻力是可比的.
- 没有涂层的在除阶段显示出相当大的阻抗升高,而IROX涂层的显示出显著减弱的阻抗升高 (每个阶段P<.01).
结论:
- 氧化 (IROX) 涂层显著降低了猪模型中研究的系统中的除门 (DFT) 能量.
- 通过IROX涂层观察到阻抗升高的减弱表明电极极化减少.
- IROX涂层代表了一种有希望的材料修改,用于提高ICD性能.
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