鼻炎和吸入的过敏原
JAMA
|December 13, 1997
概括
过敏性鼻炎影响20%的美国人,涉及过敏原暴露引发免疫反应. 管理包括避免,药物,如抗组胺剂和鼻内类固醇,和免疫治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
背景情况:
- 过敏性鼻炎影响大约20%的美国人口.
- 诊断依赖于症状模式,体检和IgE抗体检测.
- 常见的触发因素包括花粉,真菌,动物过敏原和灰尘.
研究的目的:
- 概述过敏性鼻炎的病理生理学.
- 为了描述诊断方法.
- 审查过敏性鼻炎的管理策略.
主要方法:
- 对过敏性鼻炎的诊断标准的审查.
- 对导致过敏炎症的免疫机制的分析.
- 评估当前的治疗干预措施.
主要成果:
- 对过敏原的暴露启动了快速的杆细胞介质释放,随后是乙素和淋巴细胞的参与.
- 包括中白素-4和-5在内的T(H) 2细胞因子,是协调过敏炎症的关键.
- 炎症引起的组织变化加剧了症状和随后的反应.
结论:
- 有效的管理需要避免过敏原.
- 间歇性过敏性鼻炎的症状是用抗组胺剂和脱血剂治疗的.
- 持久的症状可能需要鼻内类固醇,免疫疗法作为耐火病例的选择.
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