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通过PI,Cdc42和Rac1诱导了因特林介导的细胞机动性和侵入性

P J Keely1, J K Westwick, I P Whitehead

  • 1Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7365, USA. pkeely@med.unc.edu

Nature
|December 24, 1997
PubMed
概括

乳腺上皮细胞中Cdc42和Rac1的激活会破坏细胞两极分化,并促进细胞的入侵. 这个过程需要酸-3-OH激酶 (PI(3) K) 信号传导,而不是其他途径,突出PI(3) K.

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