缺少MC5-R的小鼠体内外分泌腺功能障碍:有证据表明,外分泌腺功能由黑色皮质酸协调调节
W Chen1, M A Kelly, X Opitz-Araya
1Vollum Institute, Oregon Health Sciences University, Portland 97201, USA.
Cell
|December 31, 1997
概括
梅拉诺丁-5受体 (MC5-R) 在外分泌腺功能中起着关键作用. MC5-R对于生产脂质,氨酸和蛋白质至关重要,影响排水和温度调节.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 身体生理学 身体生理学
背景情况:
- 像ACTH一样,由下垂体衍生的黑色皮质主要调节葡萄皮质激素的产生.
- 黑色素-5受体 (MC5-R) 是ACTH/MSH的广泛分布的受体,表明非类固醇的作用.
- MC5-R在各种外分腺体中高度表达,包括脂质腺,哈德尔腺,前腺和眼腺.
研究的目的:
- 为了研究由MC5-R.介导的黑色皮质的系统性作用.
- 确定MC5-R在外分泌腺的功能中的作用.
- 探索MC5-R参与脂质,氨酸和蛋白质在外分泌物中的产生.
主要方法:
- 针对性地破坏小鼠中的黑色素-5受体 (MC5-R) 基因.
- 对MC5-R淘汰赛小鼠的表型分析,重点关注皮肤屏障功能和温度调节.
- 评价脂质的生产在脂质腺.
- 哈德尔腺啡合成和眼腺蛋白分泌的分析.
主要成果:
- MC5-R淘汰赛小鼠在排水和温度调节方面表现出显著的缺陷.
- 这些缺陷与脂肪脂产量明显下降有关.
- 发现MC5-R在哈德尔腺体中对压力调节的氨酸合成至关重要.
- 眼腺对ACTH/MSH调节的蛋白质分泌需要MC5-R.
结论:
- 黑色素-5受体 (MC5-R) 对于多个外分泌腺体的正常功能至关重要.
- MC5-R调解关键的生理过程,包括脂质合成,氨酸生产和蛋白质分泌.
- 黑色皮质通过MC5-R协调表皮腺功能,影响全身生理学.
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