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通过一种抑制形来抑制受体蛋白氨酸酸酶功能的二聚化诱导的抑制

R Majeti1, A M Bilwes, J P Noel

  • 1Department of Microbiology, University of California, San Francisco, CA 94143, USA.

Science (New York, N.Y.)
|January 24, 1998
PubMed
概括

类似受体蛋白氨酸酸酶 (RPTPs) 的功能通过二分化来调节. 突变的EGFR-CD45仿真体揭示了一个模型,其中一个RPTPalpha酸酶域阻断了另一个的催化部位,抑制了功能.

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