生物化学检测左心室缩功能障碍的生物化学检测
T A McDonagh1, S D Robb, D R Murdoch
1Cardiology Department, Western Infirmary, Glasgow, UK.
Lancet (London, England)
|January 20, 1998
概括
血大脑尿性 (BNP) 水平可以有效地选一般人群的左心室缩功能障碍. 在患有这种心脏病的人群中发现了更高的BNP度,这表明其在早期检测中的实用性.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 诊断医学 诊断医学 诊断医学
背景情况:
- 关于用于检测左心室缩功能障碍的性尿素的先前研究可能因对照组中心脏病发病率较高而受到偏差.
- 这项研究研究了血N端心脏内尿素 (NT-ANP) 和大脑内尿素 (BNP) 在检测左心室缩功能障碍方面的有效性.
研究的目的:
- 评估NT-ANP和BNP的诊断准确性,以确定一般人口样本中的左心室缩功能障碍.
- 为了确定这些尿酸是否可以在症状和无症状的个体中检测出这种情况.
主要方法:
- 随机选择的2000名来自英国格拉斯哥的25-74岁的参与者.
- 1653名受访者填写了问卷,并接受了心声和心电图.
- 使用RIA测量了血NT-ANP和BNP水平,左心室喷射率<=30%,定义了左心室缩功能障碍.
主要成果:
- 1252名参与者拥有完整的数据进行分析.
- 在患有左心室缩功能障碍的参与者中,NT-ANP和BNP度的中位数显著更高 (p < 0.001).
- 在所有参与者中,BNP度>=17.9 pg/mL显示左心室缩功能障碍的灵敏度为77%,特异性为87%.
结论:
- 血BNP测量是一种潜在的成本效益查方法,用于一般人群的左心室缩功能障碍.
- 在高风险人群中使用BNP进行有针对性的查可以提高其有效性.
- 在症状和无症状的左心室缩功能障碍中,NT-ANP和BNP水平都升高.
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