吸烟和动脉样硬化进展:社区动脉样硬化风险研究 (ARIC)
G Howard1, L E Wagenknecht, G L Burke
1Department of Public Health Sciences of Wake Forest University, Winston-Salem, NC 27157-1063, USA. ghoward@rc.phs.bgsm.edu
JAMA
|January 24, 1998
概括
积极吸烟和环境烟草烟雾 (ETS) 暴露加快了动脉样硬化的进展. 吸烟的累积影响,以包年来衡量,与不可逆转的动脉损伤有关,特别是在糖尿病和高血压患者中.
科学领域:
- 心血管科学 心血管科学
- 公共卫生 公共卫生
背景情况:
- 吸烟是心脏病和中风的重要危险因素.
- 主动和被动吸烟对动脉样硬化进展的影响仍然不够描述.
研究的目的:
- 调查活跃吸烟和暴露于环境烟草烟雾 (ETS) 如何影响动脉样硬化的进展.
- 量化吸烟暴露与动脉内心-中枢厚度变化之间的关联.
主要方法:
- 从社区动脉样硬化风险 (ARIC) 研究中对10,914名中年成人进行了纵向研究.
- 评估了基线的吸烟暴露,并通过超声波测量了三年内动脉内心-中枢厚度的变化.
- 调整为人口因素,心血管风险和生活方式变量.
主要成果:
- 与从未吸烟者相比,活跃吸烟增加了动脉样硬化进展的50% (目前吸烟者) 和25% (过去吸烟者).
- 与未暴露的个人相比,环境烟草烟雾 (ETS) 暴露增加了20%的进展.
- 吸烟对动脉样硬化的有害影响在糖尿病和高血压患者中被放大. 更多的包年与更快的进展相关.
结论:
- 活跃吸烟和ETS暴露都对动脉样硬化的进展有显著的贡献.
- 吸烟对患有糖尿病和高血压的人来说具有更高的风险.
- 包装年份的关联,但不是当前与过去的吸烟状态,表明吸烟引起的累积和潜在的不可逆转的动脉损伤.
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