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相关实验视频

衰老的多态核白细胞中的功能变化.

K Tanji-Matsuba1, S F van Eeden, Y Saito

  • 1University of British Columbia, Pulmonary Research Laboratory, St Paul's Hospital, Vancouver, Canada.

Circulation
|January 27, 1998
PubMed
概括
此摘要是机器生成的。

随着免疫细胞的衰老,多态核中性粒细胞 (PMN) 的功能下降. 低L-选择因的老年PMN显示了动因组合和迁移受损,表明在循环过程中发生了显著的功能变化.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 血液学 血液学 血液学

背景情况:

  • 之前的研究表明,L-选择因表达在衰老的多态核中性粒细胞 (PMN) 上下降.
  • 衰老的PMN表现出碎片化的DNA和亡的形态迹象.

研究的目的:

  • 为了比较低L-选择因 (L-selectin[low]) 的PMN与总PMN群体的功能能力.
  • 研究衰老对循环中的PMN功能的影响.

主要方法:

  • 隔离了L-selectin[低]PMN,并将它们与L-selectin[混合]PMN进行了比较.
  • 评估了有线性乙烯 (F-actin) 组合,细胞形状变化,可变形性,迁移,CD18上调和用n-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) 刺激后的过氧化产量.

主要成果:

  • 在fMLP刺激后,L-selectin[low] PMN显示F-actin组合和形状变化受损.
  • 在L-selectin[low] PMN中观察到变形性和迁移能力的降低.
  • 在L-selectin[low] PMN中发现了增强的CD18上调和过氧化的产生.

结论:

  • 随着PMN在流通中的老化,它们会经历显著的功能变化.
  • L-选择因表达水平是PMN中与年龄相关的功能变化的标志物.