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作为末期脏疾病中不良心血管风险因素的高血糖蛋白质血的前性研究
A Moustapha1, A Naso, M Nahlawi
1Department of Internal Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA.
Circulation
|January 28, 1998
概括
在末期脏病患者中,高水平的同类半氨酸显著增加心血管风险. 这项前性研究证实,高血糖蛋白血症是心血管事件和死亡率的独立预测因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 临床生物化学 临床生物化学
背景情况:
- 超homocysteinemia 是一个已知的动脉样硬化在末期脏疾病 (ESRD) 患者的风险因素.
- 以前的研究表明存在关联,但前性数据有限.
研究的目的:
- 为了前性地研究ESRD患者的总类固醇度和心血管结果之间的关联.
- 在这个人群中确定心血管疾病发病率和死亡率的独立预测因素.
主要方法:
- 167名ESRD患者的前性队列研究 (平均年龄为56.3岁).
- 随访持续时间平均为17.4个月.
- 考克斯回归分析用于确定心血管事件和死亡率的独立预测因素.
主要成果:
- 55名患者 (33%) 患有心血管事件;31人 (19%) 死亡,12人死于心血管原因.
- 在患有心血管事件或心血管死亡的患者中观察到较高的总同型氨酸水平 (43.0±48.6对比26.9±14.9μmol/L,P=.02).
- 对于心血管事件的相对风险增加1%的每1μmol/L增加的总同类半素 (RR1.01;95% CI 1.00-1.01;P=.01).
结论:
- 超homocysteinemia被证实是ESRD中心血管发病率和死亡率的独立风险因素.
- 对心血管事件的1%的相对风险增加与总同类半素每升1μmol/L的增加有关.
- 需要进一步进行干预性研究,以评估改变ESRD患者的同型半氨酸水平的影响.
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