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GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
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通过PIP2直接激活内向整流器通道,并通过Gbetagamma稳定其

C L Huang1, S Feng, D W Hilgemann

  • 1Department of Medicine, University of Texas Southwestern Medical Center at Dallas, 75235, USA. chuan1@mednet.swmed.edu

Nature
|March 5, 1998
PubMed
概括

内向整流器K+通道直接与酸丁酸4,5-双酸盐 (PIP2) 结合,这对它们的活性至关重要. 关氨酸核酸结合蛋白 (G蛋白) β-玛子单元稳定了这种PIP2-通道相互作用,增强了通道功能.

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