相关实验视频
Updated: Jul 20, 2026

12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
有证据表明,性别决定基因在进化过程中一直存在
C S Raymond1, C E Shamu, M M Shen
1Institute of Human Genetics, Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455, USA.
Nature
|March 7, 1998
概括
一个保存的基因家族,DM域,调节了各种动物类的性发育. 这一发现表明,大动物中的性别决定机制具有共同的进化起源.
科学领域:
- 分子生物学分子生物学
- 发展生物学 发展生物学
- 进化生物学 进化生物学
背景情况:
- 大多数元动物表现出两种性别,但性别决定机制被认为是跨类高度分歧.
- 之前的分子分析表明,各种动物群体在如何确定性特征方面存在显著差异.
研究的目的:
- 为了研究性别决定基因的进化保存.
- 确定不同动物类中的性调节的共同分子机制.
主要方法:
- 来自Caenorhabditis elegans的男性性调节基因mab-3的分离和表征.
- 对mab-3与Drosophila melanogaster双性 (dsx) 基因进行比较分析.
- 对含有DM域的人类同类DMT1的识别和表达分析.
主要成果:
- 在结构和功能上,C. elegans mab-3基因与D. melanogaster dsx基因有关.
- 这两种基因都编码具有保留DNA结合基因的蛋白质,称为"DM域".
- 在两种物种中,DM域蛋白调节性别特异的神经细胞分化和黄蛋白基因转录,有跨物种功能性保护的证据.
结论:
- 性调节的关键方面有一个共同的进化起源,这是由保存的DM领域提出的.
- 人类DM域基因 (DMT1) 的鉴定,在丸中表达,位于与XY性别逆转相关的区域附近,暗示它在哺乳动物的性发育中起作用.
相关概念视频
The Evidence for Evolution
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.The collection of fossils within sedimentary rocks give a record of common ancestry and often depicts the history of evolution.
Gene Evolution - Fast or Slow?
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
Gene Conversion
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
The Y Chromosome Determines Maleness
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Gene Evolution - Fast or Slow?
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
Evolution of New Traits in Microbes
Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...

