在先进的HIV-1疾病中随机对托纳维尔进行安慰剂对照试验. 先进的艾滋病毒疾病里托纳维尔研究小组
D W Cameron1, M Heath-Chiozzi, S Danner
1Department of Medicine, University of Ottawa, Ottawa General Hospital, Canada.
Lancet (London, England)
|March 11, 1998
概括
里托纳维尔显著降低了艾滋病并发症,并延长了先进的HIV-1感染和先前抗逆转录病毒治疗的患者的存活时间. 这种蛋白酶抑制剂在这个脆弱的患者群体中证明了安全性和有效性.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 里托纳维尔是一种有效的口服HIV-1蛋白酶抑制剂.
- 这项研究的重点是先进的HIV-1感染患者 (CD4计数≤100细胞/μL) 和先前的抗逆转录病毒治疗.
- 国际,多中心,随机,双盲,安慰剂受控试验设计.
研究的目的:
- 评估里托纳维尔在晚期HIV-1感染患者的安全性和疗效.
- 评估利托纳维尔对艾滋病定义事件和死亡率的影响.
- 为了确定严重预先治疗的HIV-1患者的生存益处.
主要方法:
- 1090名患者随机分配给里托纳维尔 (600毫克每天两次) 或安慰剂,以及核酸剂.
- 主要结果:时间到第一个新的或复发的艾滋病定义事件或死亡.
- 分析的随访时间中位数为28.9周和51周.
主要成果:
- 里托纳维尔组:21.9%的患者经历了艾滋病事件/死亡,而安慰剂组的37.5% (HR0.53,p<0.0001) 在28.9周.
- 由于不良症状,在利托纳维尔组中停药率较高 (21.1%) .
- 在51周,16%的利托纳维尔患者死亡,而安慰剂患者为23% (HR 0.69,p=0.0072).
结论:
- 里托纳维尔对患有先进的HIV-1病毒和广泛的先前治疗的患者是安全有效的.
- 利托纳维尔治疗降低了艾滋病并发症的风险.
- 里托纳维尔在这个患者群体中延长了生存时间.
相关概念视频
Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Antiviral Nucleoside Inhibitors
Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...


