通过使用r-hirudin对特异性血栓抑制溶解壁血栓:与肝素和阿司匹林进行比较
B J Meyer1, J J Badimon, J H Chesebro
1Department of Medicine, University Hospital Inselspital, Bern, Switzerland. bmeyer@insel.unibe.ch
Circulation
|March 12, 1998
概括
使用r-hirudin直接抑制血栓激素有效地降低了急性冠状动脉综合征中的壁面血栓大小和生长. 这种抗凝剂在较低剂量下比肝素更有效,提供了一个有前途的治疗策略.
科学领域:
- 心血管研究研究心血管研究
- 血栓形成和血液静止.
- 药理学 药理学是指药理学的学科.
背景情况:
- 余壁血栓是急性冠状动脉综合征中复发性血栓事件的危险因素.
- 了解抗血栓剂对壁状血栓的影响对于管理ACS至关重要.
研究的目的:
- 为了评估抗血栓和抗血小板药物在血栓生长期间对预先形成的壁面血栓的影响.
- 为了比较r-hirudin,肝素和阿司匹林在抑制壁面血栓进展方面的疗效.
主要方法:
- 在猪身上创建了一个壁画血栓模型,通过用猪血 perfusing 受伤的动脉壁.
- 在用r-hirudin,肝素,阿司匹林或安慰剂治疗后,以形态计量测量了血栓形成和生长.
主要成果:
- R-hirudin显著减少了48%的壁面血栓面积,并且比高剂量肝素更有效地抑制了血栓生长.
- 氨酸证明了对血栓生长的剂量依赖性抑制,与血度相反相关.
- 与安慰剂相比,单独服用阿司匹林并没有显著改变血栓大小.
结论:
- 用r-hirudin直接抑制血栓完全阻止了血栓的生长,并促进了现有的壁面血栓的溶解.
- 在模仿冠状动脉狭窄的条件下,R-hirudin在较低的抗凝血水平下比高剂量肝素更有效地管理壁膜血栓.
- 这些发现突显了直接血栓抑制剂在治疗带有壁血栓的急性冠状动脉综合征方面的潜力.
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