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Updated: Jun 22, 2026

In vitro Organoid Culture of Primary Mouse Colon Tumors
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Published on: May 17, 2013

在Dpc4 (Smad4) 和Apc基因的复合突变小鼠中,肠道瘤发生

K Takaku1, M Oshima, H Miyoshi

  • 1Banyu Tsukuba Research Institute (Merck), Japan.

Cell
|March 20, 1998
PubMed
概括

失活DPC4 (SMAD4) 基因促进了APC突变肠道瘤的恶性进展. 这突显了SMAD4在结直肠癌发展和恶性瘤中的作用.

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