在注射毒品使用者中,与黑色焦油海洛因相关的伤口肉毒症
D J Passaro1, S B Werner, J McGee
1Division of Communicable Disease Control, California Department of Health Services, Berkeley 94704, USA. dpass@ix.netcom.com
JAMA
|March 27, 1998
概括
黑色焦油海洛因 (BTH) 通过皮下或肌肉内注射是发展伤口肉毒症 (WB) 的主要危险因素. 这一发现对于治疗注射毒品使用者 (IDU) 的医疗保健提供者来说至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
背景情况:
- 伤口肉毒症 (WB) 是一种严重的麻疾病,由Clostridium botulinum神经毒素引起.
- 加利福尼亚州出现了与使用"黑"海洛因 (BTH) 相关的WB病例的增加.
研究的目的:
- 在注射毒品的人群中确定伤口肉毒症的特定危险因素.
- 了解BTH注射实践与WB发展之间的关联.
主要方法:
- 进行了一项病例控制研究.
- 通过面对面和电话采访收集了26名WB患者和110名注射药物使用者的数据.
主要成果:
- 皮下或肌肉内注射BTH与WB显著相关 (OR,13.7).
- 通过这些途径注射的BTH和WB风险之间观察到剂量反应关系.
- 清洁皮肤或配件或共享针头等做法没有影响WB风险.
结论:
- 伤口肉毒症的主要危险因素是黑海洛因的皮下或肌肉内注射.
- 医生,特别是在BTH普遍存在的美国西部,必须意识到注射药物使用者的WB风险.
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