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[18F]氧葡萄糖单光子发射计算机断层扫描:它可以取代PET和SPECT来评估心肌活力吗?
G Srinivasan1, A N Kitsiou, S L Bacharach
1Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1650, USA.
Circulation
|April 1, 1998
概括
使用[18F]氧葡萄糖 (18FDG) 追踪器的新单光子发射计算断层扫描 (SPECT) 技术与正子发射断层扫描 (PET) 高度一致,用于评估心肌活力. 虽然18FDG SPECT与相比,可以更好地检测活性的组织,但它有时可能会错误地将非活性的组织识别为活性的.
科学领域:
- 核医学是一种核医学.
- 心血管成像 - 心血管成像
- 无线电探测器技术 无线电探测器技术
背景情况:
- 高能聚合器的进步使单光子发射计算机断层扫描 (SPECT) 能够对像18F-氧糖 (18FDG) 这样的正子发射标志物进行成像.
- 这项研究比较了SPECT和正子发射断层扫描 (PET) 技术,以及18FDG和追踪剂用于心肌活力评估.
研究的目的:
- 评估18F-氧葡萄糖SPECT (18FDG SPECT) 的有效性,以评估心肌活力.
- 在患有慢性冠状动脉疾病的患者中,将18FDG SPECT与18FDG PET和SPECT进行比较.
主要方法:
- 28名患有慢性冠状动脉疾病的患者接受了18FDG SPECT,18FDG PET和 SPECT.
- 用接收器运行特征 (ROC) 曲线来分析成像模式和跟踪器之间的一致性.
主要成果:
- 在SPECT和PET之间,以及在18FDG和标记剂之间观察到良好的整体一致性,用于可行性评估.
- 在患有低射出分数 (LVEF <或 = 25%) 和严重非协同作用的患者中,类往往低估了心肌活力,特别是在下壁.
- 18FDG SPECT显示88%的协议与18FDG PET在确定在区域显示严重的缺陷的可活性心肌,但显示了27%的虚假阳性率在不可活性的组织的可活性.
结论:
- 18FDG SPECT 显著提高了检测可行的心肌的灵敏度,与 SPECT 相比.
- 尽管有所改进,18FDG SPECT可能偶尔会将不可活性的组织错误地归类为可活的,这突出了与PET交叉验证的重要性.
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