随机,双盲,安慰剂对照的阿斯科尔酸盐对患有充血性心力衰竭的患者中酸盐耐受性的预防作用的研究
H Watanabe1, M Kakihana, S Ohtsuka
1Department of Cardiology, KINU Medical Association Hospital, Mitsukaido, Ibaraki, Japan. wata-h@xa2.so-net.or.jp
Circulation
|April 1, 1998
概括
阿斯科伯酸盐 (维生素C) 可能防止心力衰竭患者的酸盐耐受性. 这种抗氧化剂通过保持cGMP水平,有助于在连续的尼甘治疗期间保持治疗效果.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 酸盐耐受性,持续酸盐治疗期间治疗效率下降,与由于超氧化物增加的cGMP产量减少有关.
- 这项研究调查了抗氧化剂在减轻酸盐耐受性的作用.
研究的目的:
- 评估阿斯科伯酸盐 (维生素C) 对患有充血性心力衰竭的患者中酸盐耐受性发展的影响,这些患者接受连续的酸甘治疗.
主要方法:
- 一项随机试验,涉及20名静脉注射尼甘的充血性心力衰竭患者.
- 患者被分配给接受安慰剂或静脉注射的 Askorbate (维生素 C) 与酸甘油一起.
- 血液动力学参数和血小板周期性瓜诺辛单酸盐 (cGMP) 水平在24小时内连续测量.
主要成果:
- 两个小组最初显示肺动脉压力下降和血小板cGMP增加后,酸甘输注.
- 在安慰剂组中,这些影响减少了18小时,表明耐受性发展.
- 阿斯科巴酸盐组在18小时后保持了肺动脉压力降低,血小板cGMP保存,血维生素E水平增加.
结论:
- 作为抗氧化剂的酸盐可能会在持续的酸盐治疗期间防止酸盐耐受性的发展.
- 这表明,对于患有充血性心力衰竭的患者,酸盐药物的疗效降低,这可能是一个潜在的治疗策略.
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