与使用印尼纳维尔相关的内脏腹部脂肪积累
K D Miller1, E Jones, J A Yanovski
1Department of Critical Care Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. kmiller@atlas.niaid.nih.gov
Lancet (London, England)
|April 3, 1998
概括
接受印尼纳维尔治疗的艾滋病毒患者可能会出现腹内脂肪增加,导致腹部症状. 这种内脏脂肪组织 (VAT) 积累与印尼纳维尔使用和增加的甘油三有关.
科学领域:
- 艾滋病毒/艾滋病研究研究
- 药理学 药理学是指药理学的学科.
- 医学成像医学成像
背景情况:
- 一些接受印尼纳维尔联合治疗的HIV-1患者报告了腹部周长和丰满度的增加.
- 该研究调查了这些症状是否与腹部脂肪分布的变化和印尼纳维尔使用有关.
研究的目的:
- 为了确定印尼纳维尔的使用是否与HIV-1患者的腹内脂肪积累增加有关.
- 探索腹部症状,内脏脂肪组织 (VAT) 和印尼纳维尔治疗之间的关系.
主要方法:
- 腹部CT扫描测量了L4脊椎水平的总脂肪组织 (TAT) 和VAT.
- 在有症状的印尼纳维尔使用者,无症状的印尼纳维尔使用者和非使用者中比较的VAT:TAT比率.
主要成果:
- 与无症状使用者 (0.59) 和非使用者 (0.40) 相比,有症状的印纳维尔使用者具有显著更高的VAT:TAT比率 (0.70).
- 与印纳维尔治疗持续时间相关的VAT:TAT比率 (r=0.47,p=0.01).
- 血清甘油三水平升高与较高的VAT:TAT比率相关.
结论:
- 印尼纳维尔治疗可能导致腹内脂肪积累,在一些HIV-1患者中引起症状.
- 需要进一步研究蛋白酶抑制剂对身体脂肪分布和潜在机制的影响.
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