绝经后激素治疗对脂蛋白度的影响. 这是PEPI调查人员. 绝经后的雌激素/孕激素干预措施
M A Espeland1, S M Marcovina, V Miller
1Section on Biostatistics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1063, USA. mespelan@rc.phs.bgsm.edu
Circulation
|April 7, 1998
概括
绝经后的激素治疗在三年内持续降低了17-23%的脂蛋白 (a) 水平. 这些减少在各种雌激素和孕激素疗法中观察到,表明对心血管风险因素的持续影响.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 以前的研究表明,更年期后的激素治疗 (HT) 可能会降低脂蛋白 (a) [Lp(a) ]水平.
- 然而,这些发现是基于来自小型或短期研究的有限数据.
研究的目的:
- 评估不同绝经后激素治疗方案对Lp (a) 水平的长期影响.
- 评估一个大型,前性的,安慰剂对照的临床试验中的Lp (a) 变化.
主要方法:
- 绝经后雌激素/孕激素干预 (PEPI) 研究是一项为期3年的随机化,安慰剂对照试验.
- 参与者包括45-65岁的绝经后妇女,接受与或没有medroxyprogesterone乙酸或微化孕激素的结合雌激素.
- 血Lp (a) 水平在基线,12个月和36个月测量.
主要成果:
- 与安慰剂相比,激素治疗显著降低了17%至23%的Lp(a) 度 (P<.0001).
- 这种降低在整个3年研究期间都保持了下降.
- 在四种活性激素治疗方案中,没有发现Lp (a) 减少的显著差异.
结论:
- 绝经后的雌激素治疗,有或没有孕激素,始终降低了血Lp (a) 水平.
- 这些减少持续了三年.
- 这些发现支持HT在管理与Lp相关的心血管风险因素方面的潜在作用.
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