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在小胚胎发生过程中,左右位置信息的转移
S M Pagán-Westphal1, C J Tabin
1Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cell
|April 18, 1998
概括
小胚胎的左右不对称是通过来自亨森节点的信号来建立的. 邻近的组织指示节点,然后信号回来诱导左侧的节点基因表达.
科学领域:
- 发育生物学 发展生物学
- 胚胎学 胚胎学
- 遗传学 是一个遗传学.
背景情况:
- 左右不对称是基本的发育过程.
- 亨森节点在建立胚胎不对称性方面发挥着至关重要的作用.
- 控制这一过程的精确信号通路尚未得到充分理解.
研究的目的:
- 为了调查胚胎中左右信息的起源.
- 为了阐明由亨森节点启动的信号级联.
- 确定参与建立左右不对称的信号的时间和性质.
主要方法:
- 在小胚胎中的基因表达分析.
- 操纵亨森节点和相邻组织.
- 使用阻断抗体来抑制特定的信号分子.
- 探索培养物用于研究细胞与细胞的相互作用.
主要成果:
- 左右不对称性是由邻近亨森节点的组织指导的.
- 亨森节点向侧面组织发出信号,诱导左侧节点表达.
- 音速刺被确定为来自节点的关键信号.
- 对于节点诱导,需要来自对轴性介质体的二次信号.
结论:
- 左向右的信息来源于亨森节点之外.
- 一个复杂的信号级联涉及亨森节点,Sonic hedgehog和对轴性半皮,建立了胚胎左右不对称.
- 这些信号事件的时间对于适当的发展至关重要.
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