左侧内瘤的切除手术对语言功能的影响:一项前性研究
I R Whittle1, A M Pringle, R Taylor
1Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK. irw@skull.dcn.ac.ed.uk
Lancet (London, England)
|April 18, 1998
概括
对左侧脑瘤的切除手术显著改善了现有的语言障碍 (失语症) 的患者的语言功能. 非缺口症患者通常在手术后保持他们的语言能力,结果受瘤类型的影响.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 语言学的语言学.
背景情况:
- 语言障碍影响大约50%的左半球瘤患者,对患病率有很大影响.
- 切除性神经外科手术对语言功能的影响及其与瘤病理学的相关性仍然不完全理解.
研究的目的:
- 研究切除手术对左侧内瘤患者语言功能的直接影响.
- 探索瘤病理学和手术后语言结果之间的关系.
主要方法:
- 40名患有左侧内瘤的患者接受了语言评估,使用手术前和手术后的西非亚法西亚电池 (WAB) 和波士顿命名测试 (BNT).
- 收集的数据包括甲剂量,测试完成时间和瘤神经病理学.
主要成果:
- 手术前语言障碍 (失语症) 的患者在术后的口腔失语率 (AQ) 和语言率 (LQ) 均显著改善.
- 虽然13名失法症患者的病情有所改善,但他们仍然有损;质母细胞瘤患者的初始得分较差,但改善更大,尽管57%的患者仍然失法.
- 瘤类型影响了语言缺陷,与质母细胞瘤相关的得分较低,而与形质瘤,转移或脑膜瘤相比.
结论:
- 对于左侧内瘤的切除手术有效地增强了异位患者的语言功能.
- 在接受此类手术的非异发症患者中,语言功能通常保持不变.
- 瘤神经病理学在语言缺陷的存在和对治疗的反应中起着至关重要的作用.
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