毒性Helicobacter pylori菌株与缺血性心脏病的关联
V Pasceri1, G Cammarota, G Patti
1Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Circulation
|May 20, 1998
概括
慢性Helicobacter pylori感染与缺血性心脏病有关. 更有毒的CagA阳性菌株,而不仅仅是细菌,与风险增加有关,这表明它们在动脉动脉生成中发挥了作用.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 以前的研究表明,Helicobacter pylori感染和缺血性心脏病 (IHD) 之间存在联系.
- 在这种关联中,细菌毒性的作用与混因素 (年龄,社会阶级) 的作用仍然不清楚.
研究的目的:
- 调查Helicobacter pylori感染,特别是毒性CagA阳性菌株和缺血性心脏病之间的关联.
- 为了确定观察到的关联是由于细菌毒性或混因素.
主要方法:
- 病例控制研究涉及88名IHD患者和88名匹配对照.
- 评估了Helicobacter pylori感染和CagA阳性菌株的流行率.
- 根据年龄,性别,心血管风险因素和社会阶级进行调整.
主要成果:
- 在IHD患者中,Helicobacter pylori感染的发生率明显高于对照组 (40%),IHD患者的发生率高于对照组 (62%),OR=2.8.
- CagA阳性菌株的患病率在IHD患者 (43%) 与对照组 (17%),OR=3.8.8的患者中显著更高.
- 在IHD患者 (19%) 和对照患者 (23%) 之间,CagA阴性菌株的患病率没有差异,OR=0.8.
结论:
- 杆菌和IHD之间的关联与更有毒的细菌菌株有关.
- 这些发现支持了Helicobacter pylori可能通过慢性炎症促进动脉动脉生成的假设.
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